Vitiligo Treatment

Vitiligo treatment pune has been proposed to be a multifactorial disease with genetic susceptibility and environmental factors both thought to play a role.
The pigment that gives our skin its normal colour is melanin, which is made by cells known as melanocytes. It is a disease in which the body makes antibodies to its own melanocytes, and in doing so destroys them. After that the skin cannot make melanin properly, and vitiligo treatment is the result.

Vitiligo Treatment options

The aims of vitiligo treatment are repigmentation and stabilization of the depigmentation process. The choice of therapy depends on the extent, location, and activity of disease as well as the patient’s age and skin type. In general, a period of atleast 2-3 months is required to determine whether a particular treatment is effective.

Vitiligo Treatment pune
Vitiligo Treatment pune

Medical therapies
A. Corticosteroid Therapy,
Different routes of corticosteroid therapy

  1. Topical
  2. Oral
  3. Intralesional (ILS)

Topical corticosteroids are commonly used as first line treatment in children and adult.
Mechanism of action can be anti-inflammatory and immunomodulatory

B. Topical calcineurin inhibitors

Tacrolimus and Pimecrolimus.
They are immunomodulators.

C. Oral Immunosuppressive Agents

Vitiligo Treatment pune

D. Topical PUVA Therapy

PUVA ,also commonly referred to as phototherapy ,is effective for those vitiligo patients with less than 20 percent of their bodies covered with vitiligo patches. In this treatment, a thin film of a substance called psoralen is applied onto the depigmented skin for about 30 minutes before the skin is exposed to UVA light.when the skin is exposed to UVA, it turns into light pink.As the skin begins to heal,the normal colour of a patient’s skin starts return

E. Oral PUVA

Oral PUVA is recommended to patients,having more than 20 percent of their entire skin covered by depigmented vitiligo.In this method, an oral dosage of psoralen is taken around two hours before exposure to UVA light

F. UVB Phototherapy

Broadband UVB(290-320 nm)
Narrow band(311 nm)

G. Excimer Lase

The 308-nm excimer laser represents the latest advance in the concept of selective phototherapy in the treatment of chronic stable vitiligo.It is recommended when the lesions invove less than 20 percent of the body.Treatment is given twice or thrice weekly for 10-15 sittings.It acts through immunomodulation by affecting T cells.

H. Depigmentation

If half or more than half of skin is covered with vitiligo.
Monobenzone ether of hydroquinone.

Few other procedures Phenolisat

In this procedure,we apply phenol over vitiligo patch.
Phenolisation,actually produce controlled wound over vitiligo patch.so on healing,patch of vitiligo shows gradual repigmentation

Platelet Rich Plasma

PRP is an in-office,non-surgical autologus treatment derived from the pt’s own blood.
we deliver powerful platelet derived growth factors in to the vitiligo lesion.
Growth factors regulates the normal population density of melanocytes in the skin.so they are required for the normal proliferation and maintenance of melanocytes.

Dermabrasion with laser or medication

It produces contolled wound over vitiligopatches.It induces activation,proliferation and migration of melanoblast from border area.So it actually helps in gradually repigmentation over vitiligo patch.

Surgical Therapies

These therapies can be used on areas of skin with stable vitiligo conditions.

A. Mini-punch grafting

In this method,small and thick skin grafts are planted on the discoloured areas of the skin.Topical PUVA is then used to propel the process of stimulation.

B. Thin split thickness grafts

The technique is similar to mini-punch grafting but instead of taking a thick slice of skin,a thinner section is taken.It is usually used to treat the lips and hands.

Vitiligo Treatment pune

C. Suction bliseter grafting

In this method,the dermis is separated from the epidermis,using a special suction device that inadvertently causes blisters.The separated epidermis is then placed on the vitiligo section of the skin.There is less scarring.

D. Melanocyte transplantation (non-cultured melanocyte-kerationcyte transplantation procedure)

It involves separarting skin cells from normal skin and transplanting on white spots as a cell suspension after removal of upper layer of skin superficially.
The difficult to treat areas like bony surface,areola,genitals and knuckles can be treated with excellent results.